FlyBase Allele Report: Dmel\schlank[JF02502]

General Information

Symbol

Dmel\schlank^JF02502

Species

D. melanogaster

Name

FlyBase ID

FBal0242184

Feature type

allele

Associated gene

Dmel\schlank

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02502}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02502}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02502

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Kong et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

(Nelson et al., 2016)

abnormal starvation stress response | RU486 conditional, with Scer\GAL4^da.Switch.PT

(Nelson et al., 2016)

short lived, with Scer\GAL4^{Act5C.Switch.PR}

(Nelson et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing schlank^JF02502 under the control of Scer\GAL4^GMR.PU does not induce any obvious eye phenotype.

(Kong et al., 2019)

10 day old flies expressing schlank^JF02502 under the control of Scer\GAL4^da.Switch.PT and treated with RU486 from day 1 of adulthood, raised under either dietary restriction (0.5% yeast) or an ad libitum diet (5% yeast), have lower survival to acute starvation as compared to controls; flies expressing schlank^JF02502 under the control of Scer\GAL4^da.Switch.PT and treated with RU486 from day 1 of adulthood, raised under dietary restriction (0.5% yeast) or an ad libitum diet (5% yeast), have lower body mass and lower triglyceride content than controls.

Flies expressing schlank^JF02502 under the control of Scer\GAL4^{Act5C.Switch.PR} and treated with RU486 from day 1 of adulthood, raised under either dietary restriction (0.5% yeast) or an ad libitum diet (5% yeast), have reduced lifespan than controls.

(Nelson et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

schlank^JF02502/Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP

(Kong et al., 2019)

Other

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP, schlank^JF02502 has increased cell death phenotype

(Kong et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

schlank^JF02502/Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP

(Kong et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The eye defects induced by the expression of Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU (rough eye and depigmentation) are enhanced by the co-expression of schlank^JF02502, even leading to necrotic patches.

(Kong et al., 2019)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29340

y¹ v¹; P{TRiP.JF02502}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Lag1^JF02502

schlank^JF02502

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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