FB2024_03 , released June 25, 2024
Allele: Dmel\tutlHL01565.UAS
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General Information
Symbol
Dmel\tutlHL01565.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241905
Feature type
allele
Associated gene
Dmel\tutl
Associated Insertion(s)
Carried in Construct
P{UAS-tutl.HL01565}
Key Links
Transgenic product class
cDNA
(Al-Anzi and Wyman, 2009)
wild_type
(Al-Anzi and Wyman, 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Al-Anzi and Wyman, 2009)
wild_type
(Al-Anzi and Wyman, 2009)
Mutagen
in vitro construct
(Al-Anzi and Wyman, 2009)
Progenitor genotype
Carried in construct
P{UAS-tutl.HL01565}
Cytology
Description

UASt regulatory sequences drive expression of tutl coding sequences corresponding to the HL01565 isoform.

(Al-Anzi and Wyman, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
tutl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-neuronal expression of the membrane-bound tutlHL01565.Scer\UAS isoform under the control of Scer\GAL4elav-C155 does not generate a phenotype.

      Overexpression of tutlHL01565.Scer\UAS under the control of Scer\GAL4sca-109-68, Scer\GAL4how-24B or Scer\GAL4G14 produces branching of the ISNd nerve, stalling of motor nerves, with some nerves, such as the transverse nerve, innervating muscles that are not their normal targets.

      Overexpression of tutlHL01565.Scer\UAS in a wild-type background using the retina-specific Scer\GAL4GMR.PF produces neuronal defects in that many retinal axons stall before reaching their targets and some sprout extra axonal processes.

      (Al-Anzi and Wyman, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4sim.PS/tutlHL01565.UAS rescues tutlex383

      (Al-Anzi and Wyman, 2009)

      Scer\GAL4elav-C155/tutlHL01565.UAS rescues tutlex383

      (Al-Anzi and Wyman, 2009)

      Scer\GAL4sim.PS/tutlHL01565.UAS rescues Df(2L)ed-dp/tutlex383

      (Al-Anzi and Wyman, 2009)

      Scer\GAL4elav-C155/tutlHL01565.UAS rescues Df(2L)ed-dp/tutlex383

      (Al-Anzi and Wyman, 2009)
      Fails to rescue

      Scer\GAL4repo/tutlHL01565.UAS fails to rescue tutlex383

      (Al-Anzi and Wyman, 2009)

      Scer\GAL4repo/tutlHL01565.UAS fails to rescue Df(2L)ed-dp/tutlex383

      (Al-Anzi and Wyman, 2009)
      Comments

      Post-mitotic neuronal expression of tutlHL01565.Scer\UAS under the control of either Scer\GAL4sim.PS or Scer\GAL4elav-C155 fully rescues the midline crossing defects found in tutlex383 and tutlex383/Df(2L)ed-dp mutants. Expression under the control of Scer\GAL4repo does not rescue the phenotype, indicating that expression near the midline is important for rescue.

      (Al-Anzi and Wyman, 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tutlHL01565.Scer\UAS
      tutlHL01565.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)