FB2024_03 , released June 25, 2024
Allele: Dmel\UbqnUAS.cLa
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General Information
Symbol
Dmel\UbqnUAS.cLa
Species
D. melanogaster
Name
FlyBase ID
FBal0241240
Feature type
allele
Associated gene
Dmel\Ubqn
Associated Insertion(s)
Carried in Construct
P{UAS-Ubqn.L}
Key Links
Transgenic product class
wild_type
(Li et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Li et al., 2007)
Mutagen
in vitro construct
(Li et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Ubqn.L}
Cytology
Description

UASt regulatory sequences drive expression of full-length Ubqn coding sequences.

(Li et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ubqn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by Psn+14.UAS
      (Li et al., 2007)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of UbqnScer\UAS.cLa in the CNS under the control of Scer\GAL4elav-C155 does not generate statistically significant differences in life-span compared to control flies.

      Overexpression of UbqnScer\UAS.cLa in the wing disc under the control of Scer\GAL4sd-SG29.1 results in the development of ectopic veins near L2 vein and bridges between L1 and L2 veins in all the flies. Ectopic veins are also observed near the posterior cross vein and at the distal part of L5 vein.

      Overexpression of UbqnScer\UAS.cLa in the wing disc under the control of Scer\GAL4e22c causes ectopic veins primarily near the posterior cross vein and at the distal part of the L5 vein, but in only 2% of the flies,

      Overexpression of UbqnScer\UAS.cLa in the wing disc under the control of Scer\GAL4ptc-559.1 does not generate a significant phenotype.

      Overexpression of UbqnScer\UAS.cLa in the developing eye disc under the control of Scer\GAL4GMR.PF does not lead to any detectable eye abnormalities.

      (Li et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of UbqnScer\UAS.cLa with Psn+14.Scer\UAS in the developing eye under the control of Scer\GAL4GMR.PF leads to an increase in eye size compared to Psn+14.Scer\UAS single mutants. In addition, the irregular ommatidial packing and fusion are reduced and the number of ommatidia returns nearly to normal. Most strikingly, the 'bubble-bristle' phenotype is completely rescued. However, tufting is observed in many facets of the eye, where duplicated or triplicated bristles are found in single interommatidial regions.

      (Li et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      UbqnScer\UAS.cLa
      UbqnUAS.cLa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)