FB2024_03 , released June 25, 2024
Allele: Dmel\SyndUAS.cKa
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General Information
Symbol
Dmel\SyndUAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0240960
Feature type
allele
Associated gene
Dmel\Synd
Associated Insertion(s)
Carried in Construct
P{UAS-Synd.K}
Key Links
Transgenic product class
wild_type
(Kumar et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kumar et al., 2009)
Mutagen
in vitro construct
(Kumar et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Synd.K}
Cytology
Description

UASt regulatory sequences drive expression of Synd coding sequences.

(Kumar et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Synd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Mef2.PR- or Scer\GAL4tub.PU- but not Scer\GAL4elav.PU-mediated expression of SyndScer\UAS.cKa increases the width of the subsynaptic reticulum of neuromuscular junctions without affecting bouton size.

      Scer\GAL4Mef2.PR- or Scer\GAL4tub.PU-mediated expression of SyndScer\UAS.cKa induces the biogenesis of additional, relatively complex, subsynaptic reticulum.

      (Kumar et al., 2009)

      Expression of SyndScer\UAS.cKa in the motor neurons (under the control of Scer\GAL4elav-C155 has no effect on synaptic transmission.

      (Kumar et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4Mef2.PR-mediated expression of SyndScer\UAS.cKa can induce postsynaptic membrane expansions in dlg114 mutants that show highly reduced subsynaptic reticulum.

      Scer\GAL4Mef2.PR-mediated expression of SyndScer\UAS.cKa can induce postsynaptic membrane expansions in Pak11 mutants that show highly reduced subsynaptic reticulum.

      (Kumar et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SyndScer\UAS.cKa
      SyndUAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)