FB2024_03 , released June 25, 2024
Allele: Dmel\Rac1DN.UAS.cUa
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General Information
Symbol
Dmel\Rac1DN.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0240553
Feature type
allele
Associated gene
Dmel\Rac1
Associated Insertion(s)
Carried in Construct
P{UAS-Rac1.DN.U}
Key Links
Transgenic product class
dominant_negative_variant
(Rothenfluh et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Rothenfluh et al., 2006)
Mutagen
in vitro construct
(Rothenfluh et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Rac1.DN.U}
Cytology
Description

UAS regulatory sequences drive expression of dominant-negative Rac1 coding sequences.

(Rothenfluh et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Rac1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Rothenfluh et al., 2006)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.cUa
      (Cheng et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Rac1DN.UAS.cUa under the control of Scer\GAL4da.G32 leads to severe cuticle defects in the embryo.

      (Silver et al., 2019)

      Flies with expression of Rac1DN.Scer\UAS.cUa driven by Scer\GAL4ics-G4 are more sensitive to ethanol-induced sedation than controls.

      (Ojelade et al., 2015)

      Expression of dominantly negative Rac1DN.Scer\UAS under the control of Scer\GAL4whir3 causes ethanol-sensitivity.

      (Rothenfluh et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Rac1DN.UAS.cUa, Scer\GAL4ics-G4 has chemical sensitive | adult stage phenotype, non-suppressible by icsG4/icsG4

      (Ojelade et al., 2015)
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4ics-G4>Rac1DN.Scer\UAS.cUa;icsG4/icsG4 flies have the same increased sensitivity to ethanol-induced sedation seen in Scer\GAL4ics-G4>Rac1DN.Scer\UAS.cUa flies, unlike ethanol-resistant icsG4/icsG4 flies.

      (Ojelade et al., 2015)

      Overexpression of Rac1DN.Scer\UAS.cUa driven by Scer\GAL4ppk.PU abolishes enhancement of CNS axon regeneration seen in RtcaΔ/RtcaΔ larvae.

      (Song et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Rac1DN.Scer\UAS.cUa
      Rac1DN.Scer\UAS
      Rac1DN.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (7)