FB2024_03 , released June 25, 2024
Allele: Dmel\RhoGAP18BΔRC
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General Information
Symbol
Dmel\RhoGAP18BΔRC
Species
D. melanogaster
Name
FlyBase ID
FBal0240551
Feature type
allele
Associated gene
Dmel\RhoGAP18B
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Rothenfluh et al., 2006)
Progenitor genotype
RhoGAP18B1
(Rothenfluh et al., 2006)
Cytology
Description

Imprecise excision of RhoGAP18B1 P-element results in a 625bp deletion in the first RC exon, which is predicted to cause an early termination of the RC ORF.

(Rothenfluh et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Rothenfluh et al., 2006)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RhoGAP18BΔRC mutants exhibit resistance to ethanol-induced sedation.

      RhoGAP18BΔRC mutant flies exhibit significantly reduced loss-of-righting (LOR-refers to the inability of flies to regain upright posture upon mechanical stimulation) compared to control flies.

      (Rothenfluh et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      RhoGAP18B1

      (Rothenfluh et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on resistance to enthanol-induced sedation, the following RhoGAP18B alleles can be ranked from strongest to weakest as follows: RhoGAP18B3 > RhoGAP18B1 = RhoGAP18BΔRC.

      (Rothenfluh et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RhoGAP18BΔRC
      whirΔRC
      (Rothenfluh et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)