FB2024_03 , released June 25, 2024
Allele: Dmel\CragCZ085
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General Information
Symbol
Dmel\CragCZ085
Species
D. melanogaster
Name
FlyBase ID
FBal0240378
Feature type
allele
Associated gene
Dmel\Crag
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Denef et al., 2008)
Mutagen
ethyl methanesulfonate
(Denef et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: W659term.

(Denef et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:8,596,097..8,596,097 [+]
Nucleotide change:

G8596097A

Amino acid change:

W659term | Crag-PA; W659term | Crag-PB; W659term | Crag-PD

Reported amino acid change:

W659term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation

(exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base

on reported amino acid change.

(Denef et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous follicle cell clones at the poles of the egg chamber show defects in epithelial organisation, often forming a bilayer of cells.

      (Denef et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      CragCZ085 is rescued by Crag+t12.4

      (Denef et al., 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CragCZ085
      (Denef et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)