FB2024_03 , released June 25, 2024
Allele: Dmel\fonMB11923
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General Information
Symbol
Dmel\fonMB11923
Species
D. melanogaster
Name
FlyBase ID
FBal0240121
Feature type
allele
Associated gene
Dmel\fon
Associated Insertion(s)
Mi{ET1}fonMB11923
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Bajzek et al., 2012)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}fonMB11923
    Cytology
    Description

    Insertion in the first intron.

    (Bajzek et al., 2012)
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        fonMB11923 homozygotes are lethal, pupae are curved and elongated, as shown by a significant increase in the length/width axial ratio, and wandering third instar larvae present significant detachment and rounding of myofibers and a significant increase in the hemisegmental gap between dorsal oblique muscles 1 and 2 without any associated detachment of the actin cytoskeleton from the sarcolemma, as compared to controls.

        fonMB11923/Df(2L)Exel6043 transheterozygous wandering third instar larvae present an increase in the frequency of detachment and rounding of myofibers, as compared to controls.

        (Green et al., 2016)

        Homozygous pupae are elongated and bent.

        The survival of homozygous larvae after wounding at the feeding stage is not significantly different from that of wild-type controls in this assay.

        Hemolymph from homozygous and fonMB11923/Df(2L)Exel6043 wandering larvae produces longer fibres than can be drawn from wild-type larvae in a drawout assay testing coagulation.

        (Bajzek et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        fonMB11923
        (Bajzek et al., 2012, Bellen, 2009.10.19)
        fonMB
        (Green et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)