FB2024_03 , released June 25, 2024
Allele: Dmel\SytβKK112946
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General Information
Symbol
Dmel\SytβKK112946
Species
D. melanogaster
Name
FlyBase ID
FBal0238499
Feature type
allele
Associated gene
Dmel\Sytβ
Associated Insertion(s)
Carried in Construct
P{KK112946}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK112946}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK112946
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SytβKK112946 driven by Scer\GAL4phm.PO does not lead to developmental delay/arrest at the larval stage.

      (Yamanaka et al., 2015)

      Expression of SytβKK112946 RNAi under the control of Scer\GAL4ETH.Switch results in severely reduced developmental viability. Expression under the Scer\GAL4CCAP.PP driver leads to highly penetrant (over 90%) wing expansion defects in adult flies.

      (Park et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4CCAP.PP, SytβKK112946 has wing | adult stage phenotype, enhanceable by Scer\GAL4CCAP.PP/SytαGD1754

      (Park et al., 2014)
      Enhancer of
      Statement
      Reference

      SytβKK112946/Scer\GAL4CCAP.PP is an enhancer of wing | adult stage phenotype of Scer\GAL4CCAP.PP, SytαGD1754

      (Park et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The frequency and severity of the wing expansion defects observed in adult flies expressing either SytαGD1754 RNAi or SytβKK112946 RNAi under the control of Scer\GAL4CCAP.PP is significantly enhanced when the two are expressed simultaneously (all flies fail to expand their wing properly).

      (Park et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SytβKK112946
      Name Synonyms
      Secondary FlyBase IDs
        References (3)