FlyBase Allele Report: Dmel\Usp12-46[KK108313]

General Information

Symbol

Dmel\Usp12-46^KK108313

Species

D. melanogaster

Name

FlyBase ID

FBal0235494

Feature type

allele

Associated gene

Dmel\Usp12-46

Associated Insertion(s)

Carried in Construct

P{KK108313}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108313}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108313

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Aron et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of one copy of Usp12-46^KK108313 under the control of Scer\GAL4^GMR.PFa does not result in a rough eye phenotype at 29[o]C.

(Yang et al., 2014)

No phenotype is observed when CG7023^KK108313 is expressed using Scer\GAL4^sqh.PW or Scer\GAL4^elav.PU.

(Tsou et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-enhancer of abnormal eye color phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-enhancer of abnormal eye color phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313/Scer\GAL4^GMR.PFa is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PFa, rpr^UAS.C

(Yang et al., 2014)

NOT Suppressor of

Statement

Reference

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-suppressor of abnormal eye color phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-suppressor of abnormal eye color phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Other

Statement

Reference

Scer\GAL4^unspecified, Usp12-46^KK108313, ninaE^P37H.GMR has visible | adult stage phenotype

(Park et al., 2023)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313/Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PFa, rpr^UAS.C

(Yang et al., 2014)

Suppressor of

Statement

Reference

Usp12-46^KK108313/Scer\GAL4^hh-Gal4 is a suppressor of wing margin bristle | ectopic phenotype of Scer\GAL4^hh-Gal4, arr^{UAS.cPa.Tag:HA}

(Spencer et al., 2023)

Usp12-46^KK108313/Scer\GAL4^hh-Gal4 is a suppressor of wing blade phenotype of Scer\GAL4^hh-Gal4, arr^{UAS.cPa.Tag:HA}

(Spencer et al., 2023)

Usp12-46^KK108313/Scer\GAL4^bbg-C96 is a suppressor of wing margin bristle | ectopic phenotype of Scer\GAL4^bbg-C96, arr^{UAS.cPa.Tag:HA}

(Spencer et al., 2023)

Usp12-46^KK108313/Scer\GAL4^bbg-C96 is a suppressor of wing blade phenotype of Scer\GAL4^bbg-C96, arr^{UAS.cPa.Tag:HA}

(Spencer et al., 2023)

NOT Suppressor of

Statement

Reference

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Dronc^UAS.cSa, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Usp12-46^KK108313, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Dronc^{S130A.UAS.cSa}, Scer\GAL4^GMR.PFa

(Sinenko, 2017)

Other

Statement

Reference

Scer\GAL4^unspecified, Usp12-46^KK108313, ninaE^P37H.GMR has eye phenotype

(Park et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The photoreceptor depigmentation phenotype characteristic for adult flies expressing either Dronc^UAS.cSa or Dronc^{S130A.UAS.cSa} under the control of Scer\GAL4^GMR.PFa is not significantly modified by the co-expression of Usp12-46^KK108313.

(Sinenko, 2017)

Flies carrying one copy of grim^GMR.PC and expressing Usp12-46^KK108313 under the control of Scer\GAL4^GMR.PFa do not show a mutant eye phenotype.

(Yang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100586

P{KK108313}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG7023^KK108313

Usp12-46^KK108313

Usp46ⁱ²

(Spencer et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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