FlyBase Allele Report: Dmel\seq[U5]

General Information

Symbol

Dmel\seq^U5

Species

D. melanogaster

Name

FlyBase ID

FBal0230360

Feature type

allele

Associated gene

Dmel\seq

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q331term.

(Andrews et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage (with Df(2R)Exel8057)

(Andrews et al., 2009)

lethal - all die during embryonic stage (with seq^A41)

(Andrews et al., 2009)

lethal - all die during embryonic stage | recessive

(Andrews et al., 2009)

some die during embryonic stage (with Df(2R)Exel8057)

(Andrews et al., 2009)

some die during embryonic stage (with seq^A41)

(Andrews et al., 2009)

some die during embryonic stage | recessive

(Andrews et al., 2009)

Phenotype Manifest In

chaeta | somatic clone

(Andrews et al., 2009)

tormogen cell | somatic clone

(Andrews et al., 2009)

Detailed Description

Statement

Reference

Homozygous clones in the adult thorax result in a loss of hairs and a gain of socket cells. 72% of mutant sensory organ preclusters contain 2 socket cells and 5% contain 3 socket cells at 28 hours after puparium formation (APF), while at 38 hours APF, 65% contain 2 socket cells, 27% contain 3 socket cells and 3% contain 4 socket cells (wild-type precursor clusters always contain one socket cell).

(Andrews et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

seq^U5 has chaeta | somatic clone phenotype, suppressible by Scer\GAL4^{neur-GAL4-A101}/sv^UAS.cKa

(Andrews et al., 2009)

seq^U5 has tormogen cell | somatic clone phenotype, suppressible by Scer\GAL4^{neur-GAL4-A101}/sv^UAS.cKa

(Andrews et al., 2009)

seq^U5 has tormogen cell | somatic clone phenotype, suppressible by Scer\GAL4^{neur-GAL4-A101}/ham^UAS.cMa

(Andrews et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of sv^Scer\UAS.cKa under the control of Scer\GAL4^{neur-GAL4-A101} in homozygous seq^U5 clones results in external sensory organs with 1 hair (89%) or 2 hairs (11%).

Expression of ham^Scer\UAS.cMa under the control of Scer\GAL4^{neur-GAL4-A101} suppresses the gain of socket cells on the adult cuticle that is seen in seq^U5 clones.

(Andrews et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

seq²²

(Andrews et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

seq^U5

(Araújo and Casanova, 2011, Andrews et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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