FB2024_03 , released June 25, 2024
Allele: Dmel\dndd10234
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General Information
Symbol
Dmel\dndd10234
Species
D. melanogaster
Name
FlyBase ID
FBal0230336
Feature type
allele
Associated gene
Dmel\dnd
Associated Insertion(s)
P{XP}CG6678d10234
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Kakihara et al., 2008)

    loss of function allele

    (Jiang et al., 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{XP}CG6678d10234
    Cytology
    Description

    dndd10234 is caused by P-element P{XP}CG6678d10234 inserted between the genes dnd and CG6678 leaving their protein coding regions intact.

    (Kakihara et al., 2008)

    P{XP}CG6678d10234 is located 163bp upstream of dnd and affects dnd expression.

    (Jiang et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{XP}
    Regulatory region(s)
    UAS
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous dndd10234 embryos undergo apparently normal fusion of tracheal branches in the dorsal trunk.

        (Kakihara et al., 2008)

        dndd10234 mutant embryos display tracheal dorsal branch and dorsal trunk fusion defects. Dorsal branch lumenal breaks are observed in 80% of segments, and dorsal trunk constrictions are observed in 70% of segments at fusion sites.

        (Jiang et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        dndd10234 is partially rescued by dndUAS.cJa/Scer\GAL4esg-p127

        (Jiang et al., 2007)

        dndd10234 is partially rescued by Scer\GAL4esg-p127/dndG2A.UAS

        (Jiang et al., 2007)

        dndd10234 is partially rescued by dndT31N.UAS.cJa/Scer\GAL4esg-p127

        (Jiang et al., 2007)

        dndd10234 is partially rescued by Scer\GAL4esg-p127/dndQ71L.UAS.cJa

        (Jiang et al., 2007)
        Comments

        Scer\GAL4p127 driven expression of dndScer\UAS.cJa partially rescues the tracheal dorsal branch fusion defects found in dndd10234 mutant embryos from 80% to 13%.

        Scer\GAL4p127 driven expression of dndG2A.Scer\UAS rescues the tracheal dorsal branch fusion defects found in dndd10234 mutant embryos from 20% to 79% fused.

        Scer\GAL4p127 driven expression of dndT31N.Scer\UAS.cJa rescues the tracheal dorsal branch fusion defects found in dndd10234 mutant embryos from 20% to 41% fused.

        (Jiang et al., 2007)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Homozygous dndd10234 embryos express a detectable amount of dnd in their tracheal fusion cells.

        (Kakihara et al., 2008)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        dndd10234
        Name Synonyms
        Secondary FlyBase IDs
          References (2)