FlyBase Allele Report: Dmel\Cul3[mds5]

General Information

Symbol

Dmel\Cul3^mds5

Species

D. melanogaster

Name

FlyBase ID

FBal0230274

Feature type

allele

Associated gene

Dmel\Cul3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutation within the 5' UTR of the testis isoform.

(Arama et al., 2007)

Nucleotide substitution: G1114A.

(Arama et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:15,270,122..15,270,122 [-]

Nucleotide change:

G15270122A

Reported nucleotide change:

G114A

Comment:

Mutation within the 5' UTR of the testis isoform.

(Arama et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male fertile (with Cul3⁰⁶⁴³⁰)

(Arama et al., 2007)

male fertile (with Cul3^gft3)

(Arama et al., 2007)

male semi-sterile (with Cul3^gft4)

(Arama et al., 2007)

male sterile

(Arama et al., 2007)

male sterile (with Cul3^d577)

(Arama et al., 2007)

male sterile (with Cul3^gft1)

(Arama et al., 2007)

male sterile (with Cul3^gft2)

(Arama et al., 2007)

male sterile (with Cul3^GR18)

(Arama et al., 2007)

Phenotype Manifest In

spermatid

(Kaplan et al., 2010)

Detailed Description

Statement

Reference

Translocation of individualization complexes in spermatids is never observed in Cul-3^mds5 homozygotes.

(Kaplan et al., 2010)

cul-3^mds5/cul-3^gft4 males show 74 +/- 23% sterility.

(Arama et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Cul3^mds5 has spermatid phenotype, suppressible by soti^sik

(Kaplan et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Cul-3^mds5 soti^sik double mutants are infertile, but some limited translocation of individualization complexes in spermatids is observed.

(Kaplan et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Cul3⁰⁶⁴³⁰

(Arama et al., 2007)

Partially complements

Cul3^gft4

(Arama et al., 2007)

Fails to complement

Cul3^gft2

(Arama et al., 2007)

Cul3^gft1

(Arama et al., 2007)

Cul3^d577

(Arama et al., 2007)

Cul3^GR18

(Arama et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Cul-3^mds5

Cul3^mds5

Z2-1062

(Arama et al., 2007)

cul-3^mds5

cul3^mds5

(Kaplan et al., 2010, Arama et al., 2007, Arama et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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