FB2024_03 , released June 25, 2024
Allele: Dmel\SlnD1
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General Information
Symbol
Dmel\SlnD1
Species
D. melanogaster
Name
FlyBase ID
FBal0230259
Feature type
allele
Associated gene
Dmel\Sln
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Jang et al., 2008)
Mutagen
Delta2-3 transposase
(Jang et al., 2008)
Progenitor genotype
SlnEP2245
(Jang et al., 2008)
Cytology
Description

Imprecise excision of SlnEP2245 generates an approximate 6kb genomic deletion, removing translation initiation sites and exons 1-5 of Sln.

(Jang et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      SlnD1 homoygous mutant larvae die with in 4 days of hatching. The mutant larvae halt food uptake a few hours after hatching and show accumulation of blue-dye-mixed food mostly in the hindgut region. Moreover, they display a smaller body size compared to controls.

      SlnD1 heterozygotes, combined with either Df(2R)BSC329 or Df(2R)ED2247 die with in 4 days of hatching. The mutant larvae halt food uptake a few hours after hatching and show accumulation of blue-dye-mixed food mostly in the hindgut region. Moreover, they display a smaller body size compared to controls.

      (Jang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      SlnD1/Sln[+] is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of sicilyE

      (Liu et al., 2017)

      SlnD1/Sln[+] is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of MarfB

      (Liu et al., 2017)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      SlnD1/Sln[+] is a suppressor | partially of adult optic lobe glial cell | somatic clone phenotype of sicilyE

      (Liu et al., 2017)

      SlnD1/Sln[+] is a suppressor | partially of lipid droplet | somatic clone | adult stage phenotype of sicilyE

      (Liu et al., 2017)

      SlnD1/Sln[+] is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of sicilyE

      (Liu et al., 2017)

      SlnD1/Sln[+] is a suppressor of adult optic lobe glial cell | somatic clone phenotype of MarfB

      (Liu et al., 2017)

      SlnD1/Sln[+] is a suppressor of lipid droplet | somatic clone | adult stage phenotype of MarfB

      (Liu et al., 2017)

      SlnD1/Sln[+] is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of MarfB

      (Liu et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lipid droplet accumulation in retinal glial cells as well as the photoreceptor degeneration observed in adult flies bearing ey>flip whole-eye clones mutant for either sicilyE or MarfB is ameliorated by combination with one copy of SlnD1.

      (Liu et al., 2017)

      Scer\GAL4Bx-MS1096, lkb1Scer\UAS.cLa-dependent reduced wing size is markedly restored in a SlnD1 heterozygous background.

      (Jang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SlnD1
      (Liu et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)