FB2024_03 , released June 25, 2024
Allele: Dmel\slsZCL2144
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General Information
Symbol
Dmel\slsZCL2144
Species
D. melanogaster
Name
FlyBase ID
FBal0230218
Feature type
allele
Associated gene
Dmel\sls
Associated Insertion(s)
P{PTT-un}slsZCL2144
Carried in Construct
Also Known As
ZCL2144, sls-GFP, Kettin-GFP
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{PTT-un}slsZCL2144
    Cytology
    Description

    Insertion in an intron between coding exons for the "Sls" and "Kettin" isoforms of sls.

    (Hudson et al., 2008)
    Allele components
    Component
    Use(s)
    Inserted element
    P{PTT-un}
    Tagged with
    EGFP
    Tag:polyHis
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  myopathy
        CEA
        (González-Morales et al., 2017)
        DOES NOT model  myopathy
        CEA with cherCPTI001403
        (González-Morales et al., 2017)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
         

        slsZCL2144, Df(3R)Exel6176 double heterozygotes model myopathy.

        (González-Morales et al., 2017)
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        slsZCL2144 heterozygotes do not exhibit obvious defects in adult indirect flight muscles, as compared to controls.

        (González-Morales et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhanced by
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        slsZCL2144, Df(3R)Exel6176 double heterozygotes frequently exhibit a lack of separation of individuals sarcomeres and accumulation of actin in the H-zone of adult indirect flight muscles, as compared to controls; this actin defect is enhanced by the additional presence of one copy of cherQ1042X, cherEPSΔ5, or chersko. slsZCL2144, cherCPTI001403 double heterozygotes, however, do not exhibit any obvious sarcomere defects, as compared to controls.

        (González-Morales et al., 2017)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        slsZCL2144
        (González-Morales et al., 2017)
        slsZCL
        (González-Morales et al., 2017)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)