FB2024_03 , released June 25, 2024
Allele: Dmel\elgi1
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General Information
Symbol
Dmel\elgi1
Species
D. melanogaster
Name
FlyBase ID
FBal0221218
Feature type
allele
Associated gene
Dmel\elgi
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Von Stetina et al., 2008)
Mutagen
P-element activity
(Von Stetina et al., 2008)
Progenitor genotype
P{EPgy2}EY10782
(Von Stetina et al., 2008)
Cytology
Description

Imprecise excision of the P{EPgy2}EY10782 insertion, resulting in a 783bp deletion that removes the first two exons of the elgi transcription unit.

(Von Stetina et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      elgi1/elgi1, elgi1/elgi2 and elgi1/Df(3L)BSC575 (but not elgi1/+) flies exhibit a significant increase in size of the wing and a significantly reduced spacing between the anterior and posterior cross veins when compared to control adults.

      elgi1 homozygotes exhibit significantly larger wing discs when compared to control third instar larvae.

      elgi1/elgi1 and elgi1/Df(3L)BSC575 flies do not exhibit any defect in wing hair polarity when compared to control adults.

      (Misra and Irvine, 2019)

      Mutant females have normal ovarian morphology and are fertile, but progression from prophase I to metaphase I occurs prematurely in the mutant oocytes. Nuclear envelope breakdown in the mutant oocytes also occurs prematurely.

      Stage 14 mutant oocytes are dehydrated, as occurs in wild-type oocytes at this stage.

      elgi1/elgi2 oocytes undergo a premature metaphase I.

      (Von Stetina et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Df(3L)BSC575, elgi1 has wing | male phenotype

      (Misra and Irvine, 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      elgi1
      (Misra and Irvine, 2019, Von Stetina et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)