FB2024_03 , released June 25, 2024
Allele: Dmel\rempAk12913
Open Close
General Information
Symbol
Dmel\rempAk12913
Species
D. melanogaster
Name
FlyBase ID
FBal0220456
Feature type
allele
Associated gene
Dmel\rempA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Deletion causing a frameshift after codon 475 that truncates the predicted open reading frame after 34 more codons.

    (Lee et al., 2008)

    1862bp deletion, resulting in a frameshift that produces premature termination of the protein.

    (Lee et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        scolopidial cilium & Johnston's organ

        (Lee et al., 2008)
        Detailed Description
        Statement
        Reference

        Hemizygous and rempA21Ci-1/rempAk12913 adults lack antennal sound-evoked potentials.

        The cilia in the antennal chordotonal organ of mutant adults lack the ciliary dilation, which is normally present at about two-thirds the length of the cilium, proximal to the dendritic cap.

        (Lee et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        rempA1

        (Lee et al., 2008)

        rempA1

        (Lee et al., 2008)
        Comments

        rempAk12913 fails to complement the behavioural and viability defects of rempA1.

        (Lee et al., 2008)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Separable from: P{lacW}exk12913.

        (Lee et al., 2008)

        The "l(2)k12913" chromosome contains an insertion in the ex gene (P{lacW}exk12913) and also contains a separate lesion (a deletion) in the rempA gene. The chromosome is recessive lethal and fails to complement rempA1. However, the ex1 allele complements the viability and behaviour defects of both the "l(2)k12913" chromosome and rempA1. This indicates that the lesion in the rempA gene and not the insertion in ex is responsible for the lethality and behavioural defects of the chromosome.

        (Lee et al., 2008)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        l(2)k12913
        (Lee et al., 2008, Lee et al., 2008)
        rempAk12913
        (Lee et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)