FB2024_03 , released June 25, 2024
Allele: Dmel\PtrEP2003
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General Information
Symbol
Dmel\PtrEP2003
Species
D. melanogaster
Name
FlyBase ID
FBal0220323
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Cytology
    Description

    Insertion upstream of Ptr.

    Allele components
    Component
    Use(s)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Expression of PtrEP2003 under the control of Scer\GAL4Ccap.PP results in widespread, gross defects in the larval Ccap/burs neuron pattern of dendritic and axonal projections. Loss of some somata and neurites is seen. Many parts of the normal larval neuritic arbor are missing, often unilaterally (e.g. LB(A3) or LLT) or are substantially scaled back in size and complexity (e.g. MA(A4). Ectopic or mistargeted neurites are also seen. Defects in axonal and dendritic pathfinding are also seen during metamorphosis in these animals, leading to bilaterally asymmetric loss of major portions of the normal neuritic arbor and the formation of ectopic neurites throughout the pharate adult central nervous system.

    Head eversion occurs normally in animals expressing PtrEP2003 under the control of Scer\GAL4Ccap.PP.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    PtrEP2003
    Name Synonyms
    Secondary FlyBase IDs
      References (1)