FB2024_03 , released June 25, 2024
Allele: Dmel\AchlJF01976
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General Information
Symbol
Dmel\AchlJF01976
Species
D. melanogaster
Name
FlyBase ID
FBal0219962
Feature type
allele
Associated gene
Dmel\Achl
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01976}
Also Known As
Achl RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
in vitro construct
(Perkins et al., 2009.1.15)
Progenitor genotype
Carried in construct
P{TRiP.JF01976}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01976
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing AchlJF01976 under the control of Scer\GAL4elav-C155 (together with UAS-Dicer2 to enhance RNAi efficiency) have heterogeneous defects in their morphology and show increased survival rate upon infection (septic injury) with either Pseudomonas aeruginosa or Staphylococcus aureus and lower bacterial load at 24 hr post-infection compared to controls. However, the overall adult lifespan of these knock-down flies (without immunological challenge) as well as their survival rate under starvation is significantly decreased.

      (Li et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4ey.PU/AchlJF01976 is a non-enhancer of visible | dominant phenotype of L2

      (Son and Choi, 2020)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4ey.PU/AchlJF01976 is a non-suppressor of visible | dominant phenotype of L2

      (Son and Choi, 2020)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4ey.PU/AchlJF01976 is a non-enhancer of eye phenotype of L2

      (Son and Choi, 2020)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4ey.PU/AchlJF01976 is a non-suppressor of eye phenotype of L2

      (Son and Choi, 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AchlJF01976
      CG17386JF01976
      Name Synonyms
      Secondary FlyBase IDs
        References (5)