FB2024_03 , released June 25, 2024
Allele: Dmel\p130CASNP4466
Open Close
General Information
Symbol
Dmel\p130CASNP4466
Species
D. melanogaster
Name
FlyBase ID
FBal0219080
Feature type
allele
Associated gene
Dmel\p130CAS
Associated Insertion(s)
P{GawB}p130CASNP4466
Carried in Construct
Also Known As
DCasP1
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Huang et al., 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}p130CASNP4466
    Cytology
    Description

    Insertion in the intron downstream of the translation start codon.

    (Huang et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Germ band retraction and dorsal closure defects are seen in 1% of p130CAS1/p130CASNP4466 embryos.

        (Tikhmyanova et al., 2010)

        Homozygous embryos show axon guidance defects characteristic of increased fasciculation in the ISNb pathway (56.0% of hemisegments), in the SNa pathway (49.0% of hemisegments) and in the central nervous system (37.7% of hemisegments).

        p130CASNP4466/Df(3L)ED201 embryos show axon guidance defects characteristic of increased fasciculation in the ISNb pathway (78.0% of hemisegments), in the SNa pathway (69.6% of hemisegments) and in the central nervous system (47.6% of hemisegments).

        (Huang et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Src42AE1/+; p130CASNP4466/Df(3L)Exel6083 mutants are viable.

        (Tikhmyanova et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        p130CASNP4466/p130CAS1 is rescued by p130CASUAS.GFP/Scer\GAL4hs.PB

        (Tikhmyanova et al., 2010)
        Partially rescued by

        p130CASNP4466/Df(3L)ED201 is partially rescued by p130CASUAS.Tag:MYC/Scer\GAL4NP4466

        (Huang et al., 2007)
        Comments

        Expression of p130CASScer\UAS.T:Avic\GFP (under the control of Scer\GAL4hs.PB) completely rescues the embryonic germ band retraction and dorsal closure defects observed in p130CAS1/p130CASNP4466 trans-heterozygotes.

        (Tikhmyanova et al., 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        DCasP1
        (Tikhmyanova et al., 2010, Huang et al., 2007)
        p130CASNP4466
        Name Synonyms
        Secondary FlyBase IDs
          References (2)