FB2024_03 , released June 25, 2024
Allele: Dmel\pumRBD.UAS
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General Information
Symbol
Dmel\pumRBD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0218254
Feature type
allele
Associated gene
Dmel\pum
Associated Insertion(s)
Carried in Construct
P{UAS-pum.RBD}
Also Known As
Pum RBD
Key Links
Transgenic product class
inframe_deletion
(Menon et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Menon et al., 2004)
Mutagen
in vitro construct
(Menon et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-pum.RBD}
Cytology
Description

The C-terminal PUF RBD (amino acids 1093-1533) of the pum cDNA is cloned downstream of UAS regulatory sequences.

(Menon et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
pum
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of pumRBD.Scer\UAS in mAL neuron clones (under the control of Scer\GAL4fru-NP0021) demasculinizes the mAL neuron.

      (Goto et al., 2011)

      Expression of

      pumRBD.Scer\UAS under the control of Scer\GAL4elav-C155 has no effect on neuromuscular junction morphology.

      (Menon et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4elav-C155/pumRBD.UAS fails to rescue pum9/pum7

      (Menon et al., 2004)
      Comments

      Expression of pumRBD.Scer\UAS at 18oC in postmitotic neurons (Scer\GAL4elav-C155) does not rescue the morphology phenotypes found in a pum9/pum7 background, in contrast to its ability to provide the early abdominal segmentation function.

      (Menon et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pumRBD.Scer\UAS
      pumRBD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)