FlyBase Allele Report: Dmel\nht[Z5347]

General Information

Symbol

Dmel\nht^Z5347

Species

D. melanogaster

Name

FlyBase ID

FBal0217818

Feature type

allele

Associated gene

Dmel\nht

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hiller et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: S166term.

(Hiller et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:15,318,350..15,318,350 [-]

Nucleotide change:

C15318350A

Reported nucleotide change:

C566A

Amino acid change:

S166term | nht-PB

Reported amino acid change:

S166term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. FlyBase protein as of July 2006 is incorrect (wrong start Met) and is awaiting update. Protein produced by cDNA AY752877 is correct.

(Hiller et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle (with Df(2L)A263)

(Hiller et al., 2004)

male sterile (with Df(2L)A263)

(Hiller et al., 2004)

male sterile (with Df(2L)ED3)

(Ryder et al., 2007)

male sterile (with Df(2L)ED800)

(Ryder et al., 2007)

male sterile (with Df(2L)ED1000)

(Ryder et al., 2007)

male sterile | recessive

(Ashburner et al., 1999.10.12)

Phenotype Manifest In

spermatocyte (with Df(2L)A263)

(Hiller et al., 2004)

testis (with Df(2L)A263)

(Hiller et al., 2004)

Detailed Description

Statement

Reference

Testes from nht^z-5347/Df(2L)A263 males contain cells at the earliest stages of spermatogenesis up through primary spermatocytes, but germ cells fail to initiate meiotic cell division and the testes fill with mature primary spermatocytes.

(Hiller et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ms(2)35Ci⁰²³¹⁶, nht^Z5347 has male fertile phenotype

(Ashburner et al., 1999.10.12)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

nht^Z5347 is rescued by nht^+t10.5

(Hiller et al., 2004)

Comments

nht^+t10.5 fully rescues the spermatocyte arrest phenotype of nht^z-5347/Df adult males.

(Hiller et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25159

nht^Z5347 cn¹ bw¹/CyO

Notes on Origin

Discoverer

Isolated in screen described in FBrf0178958.

(Hiller et al., 2004)

Zuker collection.

(Roote, 2005.5.23)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ms 14-107

(Ashburner et al., 1999.10.12)

ms(2)35Ci^14-107

nht^Z5347

nht^z-5347

(Chen et al., 2005)

nht^z5347

(Ryder et al., 2007)

Name Synonyms

Secondary FlyBase IDs

FBal0178668
FBal0101259

References (7)

Report Sections

Open Close