FB2024_03 , released June 25, 2024
Allele: Dmel\Dscam1ΔC.UAS.1.30.30.1.GFP
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General Information
Symbol
Dmel\Dscam1ΔC.UAS.1.30.30.1.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0217474
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
P{UAS-Dscam1.1.30.30.1-ΔC-GFP}
Key Links
Transgenic product class
inframe_deletion
(Zhu et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zhu et al., 2006)
Mutagen
in vitro construct
(Matthews et al., 2007, Zhu et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Dscam1.1.30.30.1-ΔC-GFP}
Cytology
Description

UASt regulatory sequences drive expression of the Dscam1 1.30.30.1 isoform. The C-terminal 358 amino acids of the cytoplasmic domain is replaced with GFP.

(Zhu et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Dscam1
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Down syndrome
      CEA with Dscam1UAS.1.30.30.2
      (Hernández et al., 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larvae expressing Dscam1.30.30.1-ΔC.Scer\UAS.T:Avic\GFP in the class I vpda neuron under the control of Scer\GAL4109(2)80 show considerable overlap of the arbors of both neurons, forming numerous branch-to-branch complexes and fasciculated bundles (this overlap is more extensive than seen in wild type). The dendrites are able to grow along each other and dendrite tips often form persistent contacts or bridges to dendritic shafts.

      (Matthews et al., 2007)

      Overexpression of DscamΔC.Scer\UAS.1.30.30.1.T:Avic\GFP under the control of Scer\GAL4Mz19 does not appear to cause a shift in the position of glomeruli in adult antennal lobes.

      (Zhu et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dscam1ΔC.Scer\UAS.1.30.30.1.T:Avic\GFP
      Dscam1ΔC.UAS.1.30.30.1.GFP
      Dscam1.30.30.1-ΔC.Scer\UAS.T:Avic\GFP
      DscamΔC.Scer\UAS.1.30.30.1.T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (4)