FB2024_03 , released June 25, 2024
Allele: Dmel\FhosA055
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General Information
Symbol
Dmel\FhosA055
Species
D. melanogaster
Name
FlyBase ID
FBal0216998
Feature type
allele
Associated gene
Dmel\Fhos
Associated Insertion(s)
PBac{5HPw+}FhosA055
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{5HPw+}FhosA055
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  muscular dystrophy
        modeled by Dg323
        (Kucherenko et al., 2011)
        modeled by DgRNAi.UAS
        (Kucherenko et al., 2011)
        Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
         

        FlyBase curator comment: Interactions with Dg[086] and/or Dg[323] were detected in a Dg[086]/+ or Dg[323]/+ background which exhibits no obvious changes in muscle morphology. Nonetheless, these interactions have been captured as 'modifier' ('exacerbates') annotations here to best capture the experimental finding and the authors' intention.

        (Kucherenko et al., 2011)
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        FhosA055 mutant flies show significant indirect flight muscle degeneration compared to controls.

        FhosA055/FhosEY09842 mutant flies show significant indirect flight muscle degeneration compared to controls.

        FhosA055/+ mutant flies exhibit temperature-induced mobility defects.

        (Kucherenko et al., 2011)

        FhosA055 homozygous mutant third instar larvae do not show any significant defects in axon migration in the brain compared to controls.

        (Marrone et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Fhos Dys double heterozygous flies (FhosA055/Df(3R)Exel6184) exhibit indirect flight muscle degeneration.

        One copy of FhosA055 does not enhance the indirect flight muscle degeneration seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU.

        One copy of FhosA055 enhances the indirect flight muscle degeneration seen when DgdsRNA.Scer\UAS is expressed under the control of Scer\GAL4tub.PU.

        FhosA055 Dg323 double heterozygous flies exhibit indirect flight muscle degeneration.

        (Kucherenko et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        FhosA055
        (Kucherenko et al., 2011, Marrone et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)