FB2024_03 , released June 25, 2024
Allele: Dmel\Med24
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General Information
Symbol
Dmel\Med24
Species
D. melanogaster
Name
FlyBase ID
FBal0216832
Feature type
allele
Associated gene
Dmel\Med
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Padgett, 2008.6.25)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When neutral marked clones are induced in the ovary, the proportion of germaria carrying marked somatic stem cells 3 weeks after clone induction is around 70% of that seen one week after clone induction. However, for Med24 homozygous clones, only 11% of the germaria carrying marked somatic stem cells at 1 week after induction still do so at 2 weeks after induction. By 3 weeks, no marked somatic stem cells are present in germaria.

      Med24 homozygous clones in the ovarian follicle cells contain about 70% the number of cells as their wild-type twin-spot clones.

      (Kirilly et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The loss of Med24 homozygous mutant somatic stem cells from germaria is partially suppressed when those clones are also BacA\p35Scer\UAS.cHa; Scer\GAL4αTub84B.PL (Scer\GAL80 method).

      (Kirilly et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Padgett

      (Padgett, 2008.6.25)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Med24
      MedAF33
      (Padgett, 2008.6.25, Kirilly et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)