FlyBase Allele Report: Mmus\Pnpla6[UAS.cMa]

General Information

Symbol

Mmus\Pnpla6^UAS.cMa

Species

M. musculus

Name

FlyBase ID

FBal0215614

Feature type

allele

Associated gene

Mmus\Pnpla6

Associated Insertion(s)

Carried in Construct

P{UAS-Mmus\Pnpla6.M}

Transgenic product class

wild_type

(Muhlig-Versen et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Muhlig-Versen et al., 2005)

Mutagen

in vitro construct

(Muhlig-Versen et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-Mmus\Pnpla6.M}

Cytology

Description

UAS regulatory sequences drive expression of Mmus\Pnpla6 coding sequences.

(Muhlig-Versen et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mmus\Pnpla6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Mmus\Pnpla6^UAS.cMa, Scer\GAL4^loco.PU is a suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of Scer\GAL4^loco.PU, sws^GD3277

(Dutta et al., 2016)

Scer\GAL4^elav-C155/Mmus\Pnpla6^UAS.cMa is a suppressor of abnormal neuroanatomy phenotype of sws¹

(Muhlig-Versen et al., 2005)

Scer\GAL4^loco.1.3/Mmus\Pnpla6^UAS.cMa is a suppressor of abnormal neuroanatomy phenotype of sws¹

(Muhlig-Versen et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Mmus\Pnpla6^UAS.cMa, Scer\GAL4^loco.PU is a suppressor of cell body rind of adult lamina | adult stage | progressive phenotype of Scer\GAL4^loco.PU, sws^GD3277

(Dutta et al., 2016)

Scer\GAL4^elav-C155/Mmus\Pnpla6^UAS.cMa is a suppressor of neuropil phenotype of sws¹

(Muhlig-Versen et al., 2005)

Scer\GAL4^elav-C155/Mmus\Pnpla6^UAS.cMa is a suppressor of CNS glial cell phenotype of sws¹

(Muhlig-Versen et al., 2005)

Scer\GAL4^loco.1.3/Mmus\Pnpla6^UAS.cMa is a suppressor of CNS glial cell phenotype of sws¹

(Muhlig-Versen et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Mmus\NTE^Scer\UAS.cMa significantly suppresses vacuolization of the lamina cortex in 14 day old flies with sws^GD3277 driven by Scer\GAL4^loco.PU.

(Dutta et al., 2016)

Neuronal expression of Mmus\NTE^Scer\UAS.cMa, under the control of Scer\GAL4^elav-C155 rescues some aspects of the neuronal degeneration, namely the vacuolisation in the neuropil.

Glial expression of Mmus\NTE^Scer\UAS.cMa, under the control of Scer\GAL4^loco.1.3 rescues the glial phenotype.

Expression of Mmus\NTE^Scer\UAS.cMa in either neurons or glia (under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^loco.1.3) restores the wild-type NTE-like activity (NTE-neuropathy target esterase).

(Muhlig-Versen et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mmus\NTE^Scer\UAS.cMa

Mmus\Pnpla6^Scer\UAS.cMa

Mmus\Pnpla6^UAS.cMa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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