FB2024_03 , released June 25, 2024
Allele: Dmel\lvaDN.UAS
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General Information
Symbol
Dmel\lvaDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0215589
Feature type
allele
Associated gene
Dmel\lva
Associated Insertion(s)
Carried in Construct
P{UAS-lva.DN}
Also Known As
LvaDN
Key Links
Transgenic product class
dominant_negative_variant
(Ye et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Ye et al., 2007)
Mutagen
in vitro construct
(Ye et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-lva.DN}
Cytology
Description

UAS regulatory sequences drive expression of a dominant negative form of lva.

(Ye et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
lva
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dendrite & dendritic arborising neuron, with Scer\GAL4477

      (Ye et al., 2007)

      dendritic arborizing neuron, with Scer\GAL4109(2)80

      (Lin et al., 2015)

      Golgi apparatus & dendritic arborising neuron, with Scer\GAL4477

      (Ye et al., 2007)
      Detailed Description
      Statement
      Reference

      Expression of lvaDN.Scer\UAS in dendritic arborising neurons under the control of Scer\GAL4109(2)80 causes dendrite reduction and field shrinkage.

      (Lin et al., 2015)

      Expression of lvaDN.Scer\UAS under the control of Scer\GAL4477 in class IV dendritic arborization (da) neurons alters the distribution of Golgi outposts in these cells. In the distal part of the dendritic arbors, the size of the Golgi outposts is decreased, while in the proximal part of the dendritic arbors, the size of the Golgi outposts is increased. The number and size of Golgi structures in the soma of these cells is unaltered. The number of dendritic branches in distal dendrites is dramatically reduced, while that in proximal dendrites is increased in these cells.

      (Ye et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4109(2)80, lvaDN.UAS has abnormal neuroanatomy phenotype, suppressible | partially by Lrrk[+]/Lrrke03680

      (Lin et al., 2015)
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of Lrrke03680 suppresses the reduction in dendritic ends seen when lvaDN.Scer\UAS is expressed in dendritic arborizing neurons under the control of Scer\GAL4109(2)80. Adding one copy of Df(3R)del6 further suppresses the phenotype.

      (Lin et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      LvaDN
      (Du et al., 2021, Ye et al., 2007)
      lvaDN.Scer\UAS
      lvaDN.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)