Amino acid replacement: D26A.
Amino acid replacement: K57I.
S2 cells expressing TrxTD26A.K57I.Scer\UAS under the control of Scer\GAL4Act5C.PHb show increased viability under oxidative stress (induced by hydrogen peroxide) compared to control cells.
TrxTD26A.K57I.UAS/Scer\GAL4elav.PLu is a suppressor of abnormal locomotor behavior phenotype of Hsap\GPR37UAS.cYa
TrxTD26A.K57I.UAS/Scer\GAL4elav.PLu is a suppressor of abnormal locomotor behavior phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA
TrxTD26A.K57I.UAS/Scer\GAL4elav.PLu is a suppressor of dopaminergic neuron phenotype of Hsap\GPR37UAS.cYa
Co-expression of TrxTD26A.K57I.Scer\UAS improves the average climbing activity of 50 day old flies expressing Hsap\GPR37Scer\UAS.cYa under the control of Scer\GAL4elav.PLu.
Co-expression of TrxTD26A.K57I.Scer\UAS significantly rescues the reduction in the number of dopaminergic neurons in the dorsomedial clusters of the brain seen in 50 day old flies expressing Hsap\GPR37Scer\UAS.cYa under the control of Scer\GAL4elav.PLu.
The severe reduction in climbing ability seen in 50 day old flies expressing Hsap\MJDtr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PLu is partially suppressed by co-expression of TrxTD26A.K57I.Scer\UAS.
Carried in plasmid "TrxT(D26A/K57I)", transfected into S2 cells and used to study the ability of the protein produced to protect cells from oxidative stress.