FB2024_03 , released June 25, 2024
Allele: Dmel\TrxTC35A.UAS
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General Information
Symbol
Dmel\TrxTC35A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0212092
Feature type
allele
Associated gene
Dmel\TrxT
Associated Insertion(s)
Carried in Construct
P{UAS-TrxT.C35A}
Key Links
Transgenic product class
missense_variant
(Umeda-Kameyama et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Umeda-Kameyama et al., 2007)
Mutagen
in vitro construct
(Umeda-Kameyama et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-TrxT.C35A}
Cytology
Description

Amino acid replacement: C35A.

(Umeda-Kameyama et al., 2007)

UAS regulatory sequences drive expression of a mutated TrxT cDNA.

(Umeda-Kameyama et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
TrxT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      S2 cells expressing TrxTC35A.Scer\UAS under the control of Scer\GAL4Act5C.PHb show increased viability under oxidative stress (induced by hydrogen peroxide) compared to control cells.

      (Umeda-Kameyama et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of TrxTC35A.Scer\UAS improves the average climbing activity of 50 day old flies expressing Hsap\GPR37Scer\UAS.cYa under the control of Scer\GAL4elav.PLu.

      Co-expression of TrxTC35A.Scer\UAS significantly rescues the reduction in the number of dopaminergic neurons in the dorsomedial clusters of the brain seen in 50 day old flies expressing Hsap\GPR37Scer\UAS.cYa under the control of Scer\GAL4elav.PLu.

      The severe reduction in climbing ability seen in 50 day old flies expressing Hsap\MJDtr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PLu is partially suppressed by co-expression of TrxTC35A.Scer\UAS.

      (Umeda-Kameyama et al., 2007)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in plasmid "pUAS-TrxT(C35A)", transfected into S2 cells and used to study the ability of the protein produced to protect cells from oxidative stress.

      (Umeda-Kameyama et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TrxTC35A.Scer\UAS
      TrxTC35A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)