FB2024_04 , released June 25, 2024
Allele: Dmel\hiwGD14101
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General Information
Symbol
Dmel\hiwGD14101
Species
D. melanogaster
Name
FlyBase ID
FBal0209691
Feature type
allele
Associated gene
Dmel\hiw
Associated Insertion(s)
Carried in Construct
P{GD14101}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD14101}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD14101
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Third instar larvae expressing hiwGD14101 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4ppk.1.9 display hypersensitive behavioral response (shortened latency till response to 42[o]C thermal probe stimulus) in a thermal nociception assay. However, hiwGD14101 RNAi expression does not affect dendrite coverage in the ddaC dorsal multidendritic neurons compared to controls.

      (Honjo et al., 2016)

      Expression of hiwGD14101 under the control of any of Scer\GAL4NP4132, Scer\GAL4NP7175 or Scer\GAL4NP6024 results in enhanced aversive long term memory.

      Expression of hiwGD14101 under the control of either Scer\GAL4NP4132 or Scer\GAL4NP7175 (limited to 4 days using Scer\GAL80ts.αTub84B) results in enhanced aversive long term memory formation compared with controls.

      (Huang et al., 2012)

      Adults expressing hiwGD14101 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in a weak flyer phenotype.

      (Schnorrer et al., 2010)

      Expression of hiwGD14101 in the developing eye under the control of Scer\GAL4GMR.PF leads to a slight rough eye with disruption to eye bristles.

      (Doumanis et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of hiwGD14104 in the developing eye under the control of Scer\GAL4GMR.PF enhances the loss of pigment seen in mutant flies co-expressing Hsap\HTT152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP and Hsap\HTT48Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1 under the control of Scer\GAL4GMR.PF.

      (Doumanis et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hiwGD14101
      Name Synonyms
      Secondary FlyBase IDs
        References (9)