UASt regulatory sequences drive expression of an inverted repeat.
FlyBase curator comment: 'coenzyme Q10 deficiency disease' subtype 'primary coenzyme Q10 deficiency 6' is associated with gene COQ6. Coq6GD4930, when driven in pericardial nephrocytes (Scer\GAL4Ugt36A1.PK) serves to model the nephrotic syndrome phenotype of 'primary coenzyme Q10 deficiency 6'.
Adult flies expressing CG7277GD4930 under the control of Scer\GAL4Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.
Adults expressing CG7277GD4930 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Expression of CG7277GD4930 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) results in viable flies or partial lethality, depending on the particular P{GD4930} insertion line used.