UASt regulatory sequences drive expression of an inverted repeat.
Expression of Gba1bGD10253 under the control of Scer\GAL4elav.PU leads to significant decrease in the adult survival rate, climbing ability and sleep time compared to age-matched controls.
The brains of one-week old flies expressing Gba1bGD10253 under the control of Scer\GAL4elav-C155 exhibit a decrease in glucocerebrosidase activity compared with controls.
Adults expressing Gba1bGD10253 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.