FB2024_03 , released June 25, 2024
Allele: Dmel\Atg6GD11647
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General Information
Symbol
Dmel\Atg6GD11647
Species
D. melanogaster
Name
FlyBase ID
FBal0198787
Feature type
allele
Associated gene
Dmel\Atg6
Associated Insertion(s)
Carried in Construct
P{GD11647}
Also Known As
UAS-atg6RNAi, UAS-Atg6 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD11647}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD11647
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cFa
      (M'Angale and Staveley, 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Atg6GD11647 under the control of Scer\GAL4Mef2.PU have similar lifespan and locomotion as wild-type controls.

      (Xu et al., 2019)

      The expression of Atg6GD11647 under the control of Scer\GAL4GMR.PU leads to a significant increase in the number of ommatidia and disrupts the ommatidial array, as compared to controls. Expression under the control of Scer\GAL4Ddc.PL leads to a significant decrease in longevity and to a progressive decrease in adult locomotor ability in climbing assays, as compared to controls.

      (M'Angale and Staveley, 2016)

      Adults expressing Atg6GD11647 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      Atg6GD11647/Scer\GAL4fkh.PU is a non-enhancer of salivary gland | pupal stage phenotype of mir-14Δ1

      (Nelson et al., 2014)
      Suppressor of
      Statement
      Reference

      Atg6GD11647, Scer\GAL4GMR.PU is a suppressor | partially of eye phenotype of Ire1UAS.Tag:V5, Scer\GAL4GMR.PU

      (Zheng et al., 2023)
      NOT Suppressor of
      Statement
      Reference

      Atg6GD11647/Scer\GAL4fkh.PU is a non-suppressor of salivary gland | pupal stage phenotype of mir-14Δ1

      (Nelson et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      w The decreased number of ommatidia and the disrupted ommatidial array induced by the expression of Atg6GD11647 under the control of Scer\GAL4GMR.PU are suppressed by the co-expression of BuffyScer\UAS.cQa.

      (M'Angale and Staveley, 2016)

      Co-expression of Atg6GD11647 does not significantly alter the persistent salivary gland phenotype seen in mir-14Δ1 homozygotes 24 hours after pupariation.

      (Nelson et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference

      The co-expression of Atg6GD11647 and Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4GMR.PU leads to a decrease in the number of ommatidia and consequent disruption of the ommatidial array, both of which are more severe than upon each single expression condition.

      The co-expression of Atg6GD11647 enhances the decreased longevity, but not the progressive decrease in adult locomotion, induced by the expression of Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4Ddc.PL.

      (M'Angale and Staveley, 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Atg6GD11647
      Name Synonyms
      Secondary FlyBase IDs
        References (17)