FB2024_03 , released June 25, 2024
Allele: Dmel\fhUAS.cAa
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General Information
Symbol
Dmel\fhUAS.cAa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Anderson
FlyBase ID
FBal0198443
Feature type
allele
Associated gene
Dmel\fh
Associated Insertion(s)
Carried in Construct
P{UAS-fh.A}
Key Links
Transgenic product class
cDNA
(Anderson et al., 2005)
wild_type
(Anderson et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Anderson et al., 2005)
wild_type
(Anderson et al., 2005)
Mutagen
in vitro construct
(Anderson et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-fh.A}
Cytology
Description

UASt regulatory sequences drive expression of an fh cDNA.

(Anderson et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
fh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Friedreich ataxia
      modeled by fh1
      (Chen et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fh200GAA adults expressing fhUAS.cAa under the control of Scer\GAL4da.Switch.PT exhibit sensitivity to oxidative stress induced either by hyperoxia or paraquat.

      fh200GAA adults expressing fhUAS.cAa under the control of Scer\GAL4da.Switch.PT exhibit short lifespan and reduced ability to climb when they are fed with RU486 during development but not during adulthood.

      (Russi et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      fhUAS.cAa/Scer\GAL4da.Switch.PT rescues fh18GAA

      (Russi et al., 2020)

      fhUAS.cAa/Scer\GAL4da.Switch.PT rescues fh200GAA

      (Russi et al., 2020)

      fhUAS.cAa/Scer\GAL4da.G32 rescues fh1

      (Chen et al., 2016)

      fhUAS.cAa/Scer\GAL4ninaE.PT rescues fh1

      (Chen et al., 2016)
      Fails to rescue

      fhUAS.cAa/Scer\GAL4repo.PU fails to rescue fh1

      (Chen et al., 2016)

      fhUAS.cAa/Scer\GAL4nSyb.PS fails to rescue fh1

      (Chen et al., 2016)

      fhUAS.cAa/Scer\GAL4Mef2.PU fails to rescue fh1

      (Chen et al., 2016)
      Comments

      fhScer\UAS.cAa under the control of Scer\GAL4da.G32, but not under the control of Scer\GAL4repo.PU, Scer\GAL4nSyb.PS or Scer\GAL4Mef2.PU, rescues the lethality of fh1 mutants.

      Expression of fhScer\UAS.cAa under the control of Scer\GAL4ninaE.PT rescues the neurodegeneration and electrophysiology defect seen in fh1 mutant photoreceptor clones.

      (Chen et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fhScer\UAS.cAa
      fhUAS.cAa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Anderson
      Secondary FlyBase IDs
        References (3)