FB2024_03 , released June 25, 2024
Allele: Dmel\chkMB04207
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General Information
Symbol
Dmel\chkMB04207
Species
D. melanogaster
Name
FlyBase ID
FBal0198414
Feature type
allele
Associated gene
Dmel\chk
Associated Insertion(s)
Mi{ET1}chkMB04207
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Delgado et al., 2018)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}chkMB04207
    Cytology
    Description

    Decreases CG45092/chk mRNA expression to almost undetectable levels, affecting both ORFs.

    (Delgado et al., 2018)
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        chkMB04207 heterozygous adults exhibit decreased associative olfactory memory under starvation conditions, but not when fed.

        (Silva et al., 2022)

        chkMB04207 as well as chkMB04207/Df(2R)BSC326 mutants do not show any obvious defects in the gross adult brain morphology or any deficit in larval locomotion (assessed by speed of crawling and frequency of contraction) but display significant decrease in adult climbing ability. chkMB04207 homozygotes exhibit synaptic transmission defects (increased amplitude of evoked postsynaptic currents at 1 or 2 mM external Ca[2+], no difference in amplitude is observed at low calcium levels) at larval neuromuscular junctions, have reduced adult survival rate and lower resistance to starvation (also observed with chkMB04207/chkCRSPR transheterozygotes) as compared to controls.

        (Delgado et al., 2018)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        chkMB04207 is rescued by chkUAS.cDa/Scer\GAL4repo.PU

        (Delgado et al., 2018)
        Comments

        The reduced climbing ability and increased sensitivity to starvation observed in chkMB04207 homozygous adults is rescued by Scer\GAL4repo.PU-driven expression of chkScer\UAS.cDa.

        (Delgado et al., 2018)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG3409MB04207
        (Bellen, 2007.8.28)
        ChkMB04207
        (Silva et al., 2022)
        chkMB04207
        (Delgado et al., 2018)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)