Amino acid replacement: Y1234F.
UAS regulatory sequences drive expression of mutated form of Nrg coding sequence that reduces by half the phosphorylation of the ankyrin binding motif.
abnormal neuroanatomy, with Scer\GAL4shot-OK307
giant fibers & synapse, with Scer\GAL4shot-OK307
Expression of NrgY1234F.Scer\UAS under the control of Scer\GAL4A307 has a disruptive effect on giant-synapse formation.
NrgY1234F.UAS/Scer\GAL4shot-OK307 fails to rescue Nrg849