Nucleotide substitution: C?T.
Amino acid replacement: S?L.
Amino acid replacement: S220L.
The S220L substitution is within an 'LRR' domain.
C4949015T
C?T
S220L | jet-PA; S220L | jet-PB
S220L
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
jetr mutants can be trained to light:dark LD cycles, but take longer to be re-entrained to a new schedule than wild-type flies. The behaviour of these mutant flies within LD and constant darkness is not different to wild-type flies.
While few wild-type flies show rhythmic behaviour in constant light conditions, jetr, jetr/jetc, jetr/Df(2L)Exel8012 and jetr/Df(2L)Exel7021 mutants all show rhythmic behaviour under these conditions. Additionally, jetr mutants show reduced responses to light pulses compared to wild-type flies.
jetr is partially rescued by Scer\GAL4tim.PE/jetUAS.cKa
jetr is partially rescued by jetUAS.cKa/Scer\GAL4cry.PU
Expression of the jetScer\UAS.cKa transgene, under the control of either Scer\GAL4cry.PU or Scer\GAL4tim.PE, partially rescues the reduced light response phenotype of jetr mutants.
The stability of the jet protein is reduced in jetr mutants.