FB2024_03 , released June 25, 2024
Allele: Dmel\Rho1L3
Open Close
General Information
Symbol
Dmel\Rho1L3
Species
D. melanogaster
Name
FlyBase ID
FBal0194295
Feature type
allele
Associated gene
Dmel\Rho1
Associated Insertion(s)
PBac{GAL4D,EYFP}Rho1L3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Padash Barmchi et al., 2005)
Progenitor genotype
Associated Insertion(s)
PBac{GAL4D,EYFP}Rho1L3
Cytology
Description

Inserted in the 5' UTR of Rho1 at nt160164 of GenBank scaffold AE003808.3.

(Padash Barmchi et al., 2005)
Allele components
Component
Use(s)
Inserted element
PBac{GAL4D,EYFP}
Encoded product / tool
GAL4(II-9)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos in the offspring of homozygous Rho1L3 mothers display areas of decreased actin as well as areas of excessive actin associated with rings. Actin does not remain in apical caps during metaphase in these embryos. Actin pseudocleavage furrows often appear thickened in cross-sections in mutant embryos, but they do not show extension defects.

      (Webb et al., 2009)

      Embryos derived from Rho1L3 germ-line clones develop with variable defects ranging from failure to establish organized actin structures in the most severe cases to irregular and often only partial membrane invagination in the least severe cases.

      (Padash Barmchi et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Made by mobilizing PBac{GAL4D,EYFP} using P{neoFRT}40A, P{FRT(whs)}G13 as a target chromosome.

      (Padash Barmchi et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rho1L3
      (Webb et al., 2009, Padash Barmchi et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)