FlyBase Allele Report: Dmel\sti[4]

General Information

Symbol

Dmel\sti⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0191793

Feature type

allele

Associated gene

Dmel\sti

Associated Insertion(s)

H{}sti⁴

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(D'Avino et al., 2004)

Mutagen

P-element activity

(D'Avino et al., 2004)

Progenitor genotype

Associated Insertion(s)

H{}sti⁴

Cytology

Description

sti⁴ encodes an unstable transcript with a hobo insertion in the Citron Homology Domain.

(D'Avino et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | larval stage (with Df(3L)F10)

(D'Avino et al., 2004)

abnormal mitotic cell cycle | larval stage (with sti¹)

(D'Avino et al., 2004)

abnormal mitotic cell cycle | larval stage (with sti⁵)

(D'Avino et al., 2004)

abnormal size | larval stage (with sti¹)

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage (with Df(3L)F10)

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage (with sti¹)

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage (with sti²)

(D'Avino et al., 2004)

lethal - all die before end of prepupal stage (with sti³)

(D'Avino et al., 2004)

partially lethal - majority die | adult stage (with sti⁵)

(D'Avino et al., 2004)

partially lethal - majority die | pharate adult stage (with sti⁵)

(D'Avino et al., 2004)

some die during prepupal stage | recessive

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with Df(3L)F10)

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with sti¹)

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with sti²)

(D'Avino et al., 2004)

some die during prepupal stage | recessive (with sti³)

(D'Avino et al., 2004)

Phenotype Manifest In

imaginal disc

(D'Avino et al., 2004)

imaginal disc (with Df(3L)F10)

(D'Avino et al., 2004)

imaginal disc (with sti¹)

(D'Avino et al., 2004)

imaginal disc (with sti²)

(D'Avino et al., 2004)

imaginal disc (with sti³)

(D'Avino et al., 2004)

neuroblast & chromosome (with Df(3L)F10)

(D'Avino et al., 2004)

neuroblast & chromosome (with sti¹)

(D'Avino et al., 2004)

neuroblast & chromosome (with sti⁵)

(D'Avino et al., 2004)

neuroblast | third instar larval stage (with Df(3L)F10)

(D'Avino et al., 2004)

neuroblast | third instar larval stage (with sti¹)

(D'Avino et al., 2004)

neuroblast | third instar larval stage (with sti⁵)

(D'Avino et al., 2004)

Detailed Description

Statement

Reference

sti⁴/Df(3L)F10 mutant third instar larval brains do not exhibit a mitotic index higher than in wild-type. However, they exhibit a much higher level of polyploid neuroblasts. Approximately 35% of sti⁴/Df(3L)F10 cells are 4N, 37.7% 8N, and 7.8% are over 8N. Approximately 6.5% of sti⁴/Df(3L)F10 cells exhibit a hypercondensed chromosome phenotype, in combination with 8N or more polyploidy. sti⁴/sti¹ mutant third instar larval brains do not exhibit a mitotic index higher than in wild-type. However, they exhibit a much higher level of polyploid neuroblasts. Approximately 24.2% of sti⁴/sti¹ cells are 4N, 20.9% 8N, and 16.5% over 8N. Approximately 3.3% of sti⁴/sti¹ cells exhibit a hypercondensed phenotype. sti⁵/sti⁴ mutant third instar larval brains do not exhibit a mitotic index higher than in wild-type. However, they exhibit a much higher level of polyploid neuroblasts. Approximately 50.5% of sti⁵/sti⁴ cells are 4N, 12.9% 8N, and 1.0% over 8N. sti⁵/sti⁴ third instar neuroblasts do not exhibit a hypercondensed phenotype. sti⁴ homozygous, sti⁴/Df(3L)F10, sti¹/sti⁴, sti²/sti⁴, and sti⁴/sti³ flies have very small imaginal discs and are lethal at the prepupal stage.

(D'Avino et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: P{lacW}l(3)S044823^S044823.

(Carpenter and D'Avino, 2004.9.30)

Comments

Based on lethal phase analysis the following sti alleles can be ranked from the most severe to the weakest as follows: sti³ > sti¹ = sti² = sti⁴ > sti⁵.

(D'Avino et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

448/23

(Carpenter and D'Avino, 2004.9.30)

l(3)S044823

(Carpenter and D'Avino, 2004.9.30)

sti⁴

(D'Avino et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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