FB2024_03 , released June 25, 2024
Allele: Dmel\EcR94
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General Information
Symbol
Dmel\EcR94
Species
D. melanogaster
Name
FlyBase ID
FBal0191006
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Imprecise excision, removing ~37kb, starting at the 158bp P{lacW}EcR11 insertion site and continuing to 92bp upstream of the EcR-B transcription start site.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

98% of EcR94/EcRM554fs mutants fail to pupariate. Instead, the internal tissues of these animals become unstable and undergo necrosis. In the 2% of mutants that pupariate, eversion of the anterior spiracles occurs in an abnormal position, the pupal case is sometimes misshapen and after 24 hours, pupae undergo desiccation.

75% of EcR94/EcRM554fs larvae survive to the third larval instar stages, but all die before the pupal stage.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: F2 progeny with white eyes that cannot complement the EcRM554fs mutation for viability.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
EcR94
Name Synonyms
Secondary FlyBase IDs
    References (2)