FlyBase Allele Report: Dmel\Hrs[UAS.cLa]

General Information

Symbol

Dmel\Hrs^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Lloyd

FlyBase ID

FBal0190677

Feature type

allele

Associated gene

Dmel\Hrs

Associated Insertion(s)

Carried in Construct

P{UAS-Hrs.L}

Also Known As

UAS-hrs

Key Links

Transgenic product class

cDNA

(Lloyd et al., 2002)

wild_type

(Lloyd et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Lloyd et al., 2002)

wild_type

(Lloyd et al., 2002)

Mutagen

in vitro construct

(Lloyd et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-Hrs.L}

Cytology

Description

A NotI/KpnI fragment containing the Hrs cDNA is expressed under the control of UASt sequences.

(Lloyd et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hrs

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^bbg-C96

(Pepple et al., 2007)

Phenotype Manifest In

wing, with Scer\GAL4^cv-c-C5

(Seto and Bellen, 2006)

wing margin, with Scer\GAL4^bbg-C96

(Pepple et al., 2007, Seto and Bellen, 2006)

wing margin, with Scer\GAL4^cv-c-C5

(Seto and Bellen, 2006)

wing margin bristle, with Scer\GAL4^cv-c-C5

(Seto and Bellen, 2006)

Detailed Description

Statement

Reference

Expression of Hrs^Scer\UAS.cLa under the control of Scer\GAL4^C96 results in multiple notches along the wing margin.

(Pepple et al., 2007)

Overexpression of Hrs^Scer\UAS.cLa under the control of Scer\GAL4^bbg-C96 results in a loss of wing margin tissue.

Overexpression of Hrs^Scer\UAS.cLa under the control of Scer\GAL4^C5 results in a reduction in adult wing size, with fewer bristles near the wing margin.

(Seto and Bellen, 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has visible phenotype, suppressible by lilli^unspecified

(Pepple et al., 2007)

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has visible phenotype, suppressible by Df(2L)C144

(Pepple et al., 2007)

NOT suppressed by

Statement

Reference

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has visible phenotype, non-suppressible by msk^unspecified

(Pepple et al., 2007)

Suppressor of

Statement

Reference

Hrs^UAS.cLa/Scer\GAL4^pnt-14-94 is a suppressor of increased cell number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Hrs^UAS.cLa/Scer\GAL4^pnt-14-94 is a suppressor of abnormal neuroanatomy | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has wing margin phenotype, suppressible by lilli^unspecified

(Pepple et al., 2007)

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has wing margin phenotype, suppressible by Df(2L)C144

(Pepple et al., 2007)

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has wing margin phenotype, suppressible by wg^l-12.UAS, Scer\GAL4^bbg-C96

(Seto and Bellen, 2006)

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has wing margin phenotype, suppressible by dsh^UAS.Tag:MYC, Scer\GAL4^bbg-C96

(Seto and Bellen, 2006)

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has wing margin phenotype, suppressible by fz^UAS.cPa, Scer\GAL4^bbg-C96

(Seto and Bellen, 2006)

NOT suppressed by

Statement

Reference

Hrs^UAS.cLa, Scer\GAL4^bbg-C96 has wing margin phenotype, non-suppressible by msk^unspecified

(Pepple et al., 2007)

Suppressor of

Statement

Reference

Hrs^UAS.cLa/Scer\GAL4^pnt-14-94 is a suppressor of larval neuroblast | increased number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Hrs^UAS.cLa/Scer\GAL4^pnt-14-94 is a suppressor of embryonic/larval brain | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of wg^{l-12.Scer\UAS} with Hrs^Scer\UAS.cLa, both under the control of Scer\GAL4^bbg-C96 largely suppresses the Hrs^Scer\UAS.cLa loss of margin tissue phenotype.

Co-expression of dsh^{Scer\UAS.T:Hsap\MYC} with Hrs^Scer\UAS.cLa, both under the control of Scer\GAL4^bbg-C96 largely suppresses the Hrs^Scer\UAS.cLa loss of margin tissue phenotype.

Co-expression of fz^Scer\UAS.cPa with Hrs^Scer\UAS.cLa, both under the control of Scer\GAL4^bbg-C96 largely suppresses the Hrs^Scer\UAS.cLa loss of margin tissue phenotype.

(Seto and Bellen, 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42692

y¹ w^*; P{UAS-Hrs.L}12

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hrs^Scer\UAS.cLa

Hrs^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Lloyd

(Lloyd et al., 2002)

Secondary FlyBase IDs

References (7)

Report Sections

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