FlyBase Allele Report: Dmel\Atx-1[UAS.cTa]

General Information

Symbol

Dmel\Atx-1^UAS.cTa

Species

D. melanogaster

Name

FlyBase ID

FBal0190159

Feature type

allele

Associated gene

Dmel\Atx-1

Associated Insertion(s)

Carried in Construct

P{UAS-Atx-1.T}

Also Known As

UAS-dAtx-1

Key Links

Transgenic product class

wild_type

(Tsuda et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Tsuda et al., 2005)

Mutagen

in vitro construct

(Tsuda et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-Atx-1.T}

Cytology

Description

UAS regulatory sequences drive expression of Atx-1 coding sequences.

(Tsuda et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Atx-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal dominant cerebellar ataxia

CEA

(Zhai et al., 2008)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of autosomal dominant cerebellar ataxia

is ameliorated by Nmnat^UAS.cZa

(Zhai et al., 2008)

is ameliorated by Nmnat^WR.UAS.PD

(Zhai et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Phenotype Manifest In

eye, with Scer\GAL4^ninaE.PT

(Tsuda et al., 2005)

eye photoreceptor cell, with Scer\GAL4^ninaE.PT

(Tsuda et al., 2005)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Tsuda et al., 2005)

mesothoracic bristle, with Scer\GAL4^sca-109-68

(Tsuda et al., 2005)

metathoracic bristle, with Scer\GAL4^sca-109-68

(Tsuda et al., 2005)

ommatidium, with Scer\GAL4^GMR.PF

(Tsuda et al., 2005)

rhabdomere of eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Zhai et al., 2008)

wing, with Scer\GAL4^bbg-C96

(Tsuda et al., 2005)

wing, with Scer\GAL4^cv-c-C5

(Tsuda et al., 2005)

wing margin bristle, with Scer\GAL4^bbg-C96

(Tsuda et al., 2005)

wing vein | ectopic, with Scer\GAL4^GMR.PF

(Tsuda et al., 2005)

wing vein | heat sensitive, with Scer\GAL4^cv-c-C5

(Tsuda et al., 2005)

Detailed Description

Statement

Reference

Overexpression of Scer\GAL4^GMR.PF>Atx-1^Scer\UAS.cTa induces rhabdomere degeneration.

(Zhai et al., 2008)

Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^ninaE.PT results in neurodegeneration in the eye. At 2 days after eclosion, no obvious morphological changes in the photoreceptor cells are observed. At 28 days, many large holes and a loss of cell integrity is observed. On average, five or six photoreceptor cells remain out of the eight found in normal eyes. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^GMR.PF induces eye abnormalities. The external structures of the eyes exhibit disorganised ommatidia and a loss of interommatidial bristles. They also exhibit a loss of rhabdomeres and tissue integrity. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^GMR.PF also generates extra wing-vein tissue. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^C5 in the wing pouch at 27^oC results in several vein abnormalities. Overexpression of Atx-1^Scer\UAS.cTa, under the control of Scer\GAL4^C96 in the wing margin causes bristle abnormalities including patterning defects and bristle loss. Overexpression of Atx-1^Scer\UAS.cTa in the sensory organ precursor cells under the control of Scer\GAL4^sca-109-68 causes a loss of thoracic bristles.

(Tsuda et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Atx-1^UAS.cTa, Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Atx-1^UAS.cTa, Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Atx-1^UAS.cTa, Scer\GAL4^GMR.PF has rhabdomere of eye photoreceptor cell phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Atx-1^UAS.cTa, Scer\GAL4^GMR.PF has rhabdomere of eye photoreceptor cell phenotype, suppressible by Nmnat^WR.UAS.PD, Scer\GAL4^GMR.PF

(Zhai et al., 2008)

Atx-1^UAS.cTa, Scer\GAL4^sca-109-68 has metathoracic bristle phenotype, suppressible by sens^UAS.cNa, Scer\GAL4^sca-109-68

(Tsuda et al., 2005)

Atx-1^UAS.cTa, Scer\GAL4^sca-109-68 has mesothoracic bristle phenotype, suppressible by sens^UAS.cNa, Scer\GAL4^sca-109-68

(Tsuda et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Nmnat^WR.Scer\UAS suppresses the rhabdomere degeneration phenotype induced by Scer\GAL4^GMR.PF>Atx-1^Scer\UAS.cTa.

Co-expression of Nmnat^Scer\UAS.cZa suppresses the rhabdomere degeneration phenotype induced by Scer\GAL4^GMR.PF>Atx-1^Scer\UAS.cTa.

(Zhai et al., 2008)

Coexpression of sens^Scer\UAS.cNa with Atx-1^Scer\UAS.cTa (both under the control of Scer\GAL4^sca-109-68) abolishes the loss of thoracic bristles phenotype of Atx-1^Scer\UAS.cTa overexpression

(Tsuda et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

39741

y¹ w^*; P{UAS-Atx-1.T}MBR/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Atx-1^Scer\UAS.cTa

Atx-1^UAS.cTa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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