FB2024_03 , released June 25, 2024
Allele: Dmel\mmyIL07
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General Information
Symbol
Dmel\mmyIL07
Species
D. melanogaster
Name
FlyBase ID
FBal0189901
Feature type
allele
Associated gene
Dmel\mmy
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tonning et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: I197N.

(Tonning et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,469,818..6,469,818 [-]
Nucleotide change:

T6469818A

Amino acid change:

I197N | mmy-PA; I160N | mmy-PB; I160N | mmy-PD

Reported amino acid change:

I197N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Tonning et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Weak allele. mmyIL07 larvae develop a bloated cuticle and a deformed and strongly melanised head skeleton. The cuticle of mmyIL07 larvae is stratified as in wild type, and the procuticular microfibrils appear correctly oriented. However, the procuticle contains abnormal inclusions of electron-dense material that are scattered below the epicuticle. mmyIL07 epidermal cells show septate junctions arranged in ladder-like structures as in wild type. The lumen diameter of the dorsal trunk in the mmyIL07 embryonic tracheal system is slightly irregular at stage 15 and becomes excessively elongated at stage 16. Apart from this irregularity, the tracheal system is correctly patterned.

      (Tonning et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mmyIL07
      Name Synonyms
      Secondary FlyBase IDs
        References (1)