FlyBase Allele Report: Dmel\aop[443]

General Information

Symbol

Dmel\aop⁴⁴³

Species

D. melanogaster

Name

FlyBase ID

FBal0189749

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

Carried in Construct

Also Known As

yan⁴⁴³, yan^ER443, yan^ER433

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Schober et al., 2005)

Mutagen

Progenitor genotype

Cytology

Description

The premature stop codon is predicted to result in a truncated protein that lacks most of the wild-type sequence including the MAPK phosphorylation sites and the entire ETS DNA-binding domain.

(Schober et al., 2005)

Amino acid replacement: Q111term.

(Schober et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:2,160,161..2,160,161 [-]

Nucleotide change:

C2160161T

Amino acid change:

Reported amino acid change:

Q111term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Schober et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | adult stage (with aop^E833), with aop^V105R.GFP

(Hope et al., 2018)

partially lethal - majority die (with aop^SY5)

(Hope et al., 2018)

Phenotype Manifest In

border follicle cell | somatic clone

(Schober et al., 2005)

eye (with aop^E833), with aop^V105R.GFP

(Hope et al., 2018)

eye photoreceptor cell (with aop^E833), with aop^V105R.GFP

(Hope et al., 2018)

eye photoreceptor cell | ectopic (with aop^E833), with aop^V105R.GFP

(Hope et al., 2018)

Detailed Description

Statement

Reference

Adult aop⁴⁴³/aop^E833 transheterozygotes bearing aop^V105R.GFP show a rough eye phenotype; most ommatidia show extra photoreceptor cells, particularly inner photoreceptor R7 cells, but some other miss photoreceptor cells, as compared to controls.

(Hope et al., 2018)

The majority of border cells in egg chambers with aop⁴⁴³ mutant clones fail to migrate. The border cells are connected laterally to squamous follicle cells, suggesting that they remain attached to the anterior follicular epithelium.

(Schober et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

aop⁴⁴³/aop[+] is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

aop⁴⁴³/aop[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

NOT Enhancer of

Statement

Reference

aop⁴⁴³/aop[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

NOT Suppressor of

Statement

Reference

aop⁴⁴³/aop[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

aop⁴⁴³/+ enhances the planar cell polarity (PCP) defects in the eye induced by the overexpression of dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a modifier of Ras85D in the eye in a genetic screen.

(Schober et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

aop⁴⁴³

(Weber et al., 2012)

yan⁴⁴³

(Hope et al., 2018, Olson et al., 2011, Letizia et al., 2007, Schober et al., 2005)

yan^E433

(Weber et al., 2008)

yan^E443

(Boisclair Lachance et al., 2018)

yan^ER433

(Webber et al., 2013, Webber et al., 2013)

yan^ER443

(Cassidy et al., 2019, Boisclair Lachance et al., 2018, Webber et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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