FB2024_03 , released June 25, 2024
Allele: Dmel\Mpf03008
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General Information
Symbol
Dmel\Mpf03008
Species
D. melanogaster
Name
FlyBase ID
FBal0185866
Feature type
allele
Associated gene
Dmel\Mp
Associated Insertion(s)
PBac{WH}Mpf03008
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Mpf03008
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mitochondria within mpf03008 indirect flight muscles are abnormal.

      (Momota et al., 2013)

      33.8% of mpf07253/mpf03008 adults show defects at the wing margin, where the longitudinal veins do not extend fully to the edge of the wing.

      54.5% of homozygotes and 29.4% of mpf07253/mpf03008 adults show abnormalities in the dorsal abdominal cuticle (the tergites are either missing or not fused at the dorsal midline).

      Homozygous larvae show a poor response to physical stimuli (in contrast to wild-type larvae which show a strong avoidance response). Fatbodies are smaller than normal and their lipid droplets are large in homozygous larvae.

      (Momota et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the insertion can revert the mutant wing vein and abdominal tergite phenotypes.

      (Momota et al., 2011)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG33171f03008
      CG42543f03008
      Mpf03008
      mpf03008
      (Momota et al., 2013, Momota et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)