FB2024_03 , released June 25, 2024
Allele: Dmel\lwrDN.UAS
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General Information
Symbol
Dmel\lwrDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0179000
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Ubc9DN
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UASt sequences drive expression of a dominant negative form of lwr (carries the amino acid replacements C93R and L97A).

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of lwrDN.Scer\UAS under the control of either Scer\GAL4tub or Scer\GAL4e33C prevents hatching in 18% of embryos and causes cuticle defects in some embryos. Expression of lwrDN.Scer\UAS under the control of either Scer\GAL4Cg.PA or Scer\GAL4e33C leads to increased levels of hemocytes, particularly of lamellocytes, in the hemolymph of larvae compared to wild type. In contrast, expression with the fat body-specific Scer\GAL4Lsp2.PH driver does not affect hemocyte levels.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
lwrDN.Scer\UAS
lwrDN.UAS
Name Synonyms
Secondary FlyBase IDs
    References (5)