FB2024_03 , released June 25, 2024
Allele: Dmel\par-6UAS.cKa
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General Information
Symbol
Dmel\par-6UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Knoblich
FlyBase ID
FBal0178501
Feature type
allele
Associated gene
Dmel\par-6
Associated Insertion(s)
Carried in Construct
P{UAS-par-6.K}
Also Known As
UAS-Par-6, UAS-Par6
Key Links
Transgenic product class
wild_type
(Pinheiro and Montell, 2004)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Pinheiro and Montell, 2004)
Mutagen
in vitro construct
(Pinheiro and Montell, 2004)
Progenitor genotype
Carried in construct
P{UAS-par-6.K}
Cytology
Description

UAS sequences control expression of par-6.

(Pinheiro and Montell, 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
par-6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of par-6Scer\UAS.cKa in amnioserosa under the control of Scer\GAL4332.3 has no significant phenotypic effect on actomyosin assembly-disassembly cycles.

      (David et al., 2010)

      In 1X(par-6Scer\UAS.cKa); Scer\GAL4slbo.2.6 flies, border cell migration is delayed in 15% of stage 10 egg chambers. This is increased to greater than 50% when 2 copies of par-6Scer\UAS.cKa are present.

      (Pinheiro and Montell, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of par-6Scer\UAS.cKa and aPKCCAAXWT.Scer\UAS under the control of Scer\GAL4Bx-MS1096 leads to a severe tumor phenotype in third instar larval wing discs, as compared to controls.

      (Bunker et al., 2015)

      Co-expression of par-6Scer\UAS.cKa and aPKCCAAXWT.Scer\UAS under the control of Scer\GAL4332.3 significantly reduces the network pulse frequency for actomyosin assembly-disassembly cycles. Lull times are also significantly higher than in wild-type, and have wide variation. However, pulse durations are statistically indistinguishable from those of controls. Some cells with par-6Scer\UAS.cKa plus aPKCCAAXWT.Scer\UAS overexpression never form actomyosin networks.

      (David et al., 2010)

      The percentage of stage 10 egg chambers in which border cell migration is delayed is increased in 1X(par-6Scer\UAS.cKa); Scer\GAL4slbo.2.6 flies from 15% to 83% by the presence of bazScer\UAS.cKa.

      (Pinheiro and Montell, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      J.A. Knoblich

      (Pinheiro and Montell, 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      par-6Scer\UAS.cKa
      par-6UAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Knoblich
      (Pinheiro and Montell, 2004)
      Secondary FlyBase IDs
        References (6)