FB2024_03 , released June 25, 2024
Allele: Dmel\pblΔBRCT.UAS
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General Information
Symbol
Dmel\pblΔBRCT.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0178481
Feature type
allele
Associated gene
Dmel\pbl
Associated Insertion(s)
Carried in Construct
P{UAS-pbl.ΔBRCT}
Key Links
Transgenic product class
inframe_deletion
(Smallhorn et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Smallhorn et al., 2004)
Mutagen
in vitro construct
(Smallhorn et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-pbl.ΔBRCT}
Cytology
Description

UAS sequences control expression of pbl lacking the entire C-terminal (RadECL domain and BRCT1 and 2 domains) up to the end of the BRCT2 domain, but including the nuclear localisation signal.

(Smallhorn et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
pbl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      pblΔBRCT.UAS/Scer\GAL4prd.RG1 partially rescues pbl2/pbl3

      (Smallhorn et al., 2004)
      Comments

      pblΔBRCT.Scer\UAS; Scer\GAL4prd.RG1 significantly rescues the formation of eve positive clusters of dorsal mesodermal cells in stage 11 pbl2/pbl3 embryos, but fails to rescue cytokinesis defects in these cells. The morphology of migrating mesodermal cells in these embryos is much closer to wild-type than in pbl2/pbl3 embryos.

      (Smallhorn et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pblΔBRCT.Scer\UAS
      pblΔBRCT.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)