FB2024_03 , released June 25, 2024
Allele: Dmel\HDAC3N
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General Information
Symbol
Dmel\HDAC3N
Species
D. melanogaster
Name
FlyBase ID
FBal0176117
Feature type
allele
Associated gene
Dmel\HDAC3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhu et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q57term.

(Zhu et al., 2008)

Mutation eliminates the HDAC catalytic domain.

(Zhu et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:5,474,093..5,474,093 [-]
Nucleotide change:

C5474093T

Amino acid change:

Q57term | HDAC3-PA

Reported amino acid change:

Q57term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Zhu et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous neuroblast clones result in a 20% reduction in the number of projection neurons compared to wild type. Their dendrites appear to target normally.

      Homozygous single-cell DL1 projection neuron clones show normal dendrite targeting and normal axon arborisation in the lateral horn.

      (Tea et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      HDAC3N/Hdac3[+] is an enhancer of visible | dominant phenotype of Snr1E1

      (Zraly et al., 2004)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      HDAC3N/Hdac3[+] is an enhancer of wing vein | ectopic phenotype of Snr1E1

      (Zraly et al., 2004)

      HDAC3N/Hdac3[+] is an enhancer of wing phenotype of Snr1E1

      (Zraly et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for Hdac3N leads to strong suppression of the eye colour variegation found in In(1)wm4 mutants.

      (Zhu et al., 2008)

      At 29oC, Hdac3N/+ enhances the ectopic wing vein phenotype of Snr1E1/+; 100% of flies have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. The ectopic wing vein phenotype seen in Hdac3N/Snr1E1 double heterozygotes at 29oC is partially suppressed by brm2/+.

      (Zraly et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HDAC3N
      (Tea et al., 2010)
      Hdac3N
      hdac3N
      (Zhu et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)