FlyBase Allele Report: Dmel\Src64B[UAS.cPa]

General Information

Symbol

Dmel\Src64B^UAS.cPa

Species

D. melanogaster

Name

FlyBase ID

FBal0175796

Feature type

allele

Associated gene

Dmel\Src64B

Associated Insertion(s)

Carried in Construct

P{UAS-Src64B.P}

Key Links

Transgenic product class

cDNA

(Pedraza et al., 2004)

wild_type

(Pedraza et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Pedraza et al., 2004)

wild_type

(Pedraza et al., 2004)

Mutagen

in vitro construct

(Pedraza et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-Src64B.P}

Cytology

Description

UASt sequences drive expression of a Src64B cDNA.

(Pedraza et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Src64B

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^GMR.PF

(Pedraza et al., 2004)

increased cell death, with Scer\GAL4^GMR.PF

(Pedraza et al., 2004)

increased occurrence of cell division | larval stage, with Scer\GAL4^GMR.PF

(Pedraza et al., 2004)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Pedraza et al., 2004)

eye disc | larval stage, with Scer\GAL4^GMR.PF

(Pedraza et al., 2004)

interommatidial bristle | ectopic, with Scer\GAL4^GMR.PF

(Pedraza et al., 2004)

Detailed Description

Statement

Reference

When Src64B^Scer\UAS.cPa is driven by Scer\GAL4^GMR.PF, a range of phenotypes is seen in the eye in an insertion, dose dependent and temperature sensitive manner. These range through a complete loss of the eye, through small rough eyes, rough eyes with ectopic bristles to no phenotype at all. When the developing eye disc is examined, ectopic proliferation of uncommitted cells (which usually arrest in G₁/G₀) in the disc is seen. Mutant eye discs also exhibit increased cell death.

(Pedraza et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, Src64B^UAS.cPa has increased occurrence of cell division | larval stage phenotype, enhanceable by Hsap\CDKN1A^UAS.cHa, Scer\GAL4^GMR.PF

(Pedraza et al., 2004)

NOT Enhanced by